Evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients
| Autor: | Al-Nowaiser, Abeer M., Al-Zoman, Hamad, Baskaradoss, Jagan K., Robert, Asirvatham A., Al-Zoman, Khalid H., Al-Sohail, Abdulaziz M., Al-Suwyed, Abdulaziz S., Ciancio, Sebastian G., Al-Mubarak, Sultan A. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
DNA Bacterial Male Bacteroidetes Middle Aged Aggregatibacter actinomycetemcomitans Prevotella intermedia Article Anti-Bacterial Agents Root Planing Treatment Outcome Diabetes Mellitus Type 2 Doxycycline Chronic Periodontitis Bacteroidaceae Infections Dental Scaling Humans Female Single-Blind Method Pasteurellaceae Infections Periodontal Index Porphyromonas gingivalis |
| Zdroj: | Saudi Medical Journal |
| ISSN: | 1658-3175 0379-5284 |
| Popis: | Objectives: To evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis. Methods: This 9-month multi-center, randomized, parallel, single-blinded study was conducted from different hospitals in Riyadh, Saudi Arabia between April 2010 and December 2010. A total of 76 diabetic subjects with chronic periodontitis were randomized into 2 groups: control group (CG) received only scaling and root planing (SRP), and the treatment group (TG) receiving systemic doxycycline during the reevaluation visit 45 days after the completion of SRP. Probing pocket depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were collected at baseline, 45 days after SRP, and one, 3, and 6 months after the use of systemic doxycycline. Microbiological analysis comprised the detection of Tannerella forsythia (Tf), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi) by polymerase chain reaction method. Results: Sixty-eight (33 CG and 35 TG) subjects completed the study. Greater reduction in the population of Tf, Pg, and Pi were observed in TG compared with CG in the first month after the administration of systemic doxycycline. The TG showed a significant improvement in gingival index scores compared with the CG (p |
| Databáze: | OpenAIRE |
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