| Autor: |
Clara, de Andrés, M Carmen, Rodríguez-Sáinz, M Angeles, Muñoz-Fernández, Nieves, López-Lazareno, Margarita, Rodríguez-Mahou, Angeles, Vicente, Eduardo, Fernández-Cruz, Silvia, Sánchez-Ramón |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
European cytokine network. 15(3) |
| ISSN: |
1148-5493 |
| Popis: |
Multiple sclerosis (MS) is an immune-mediated disease with a clear sex-bias that may be attributed to sex hormones, sex' linked genes or both. Here we sought to determine the evolution pattern of cortisol and sex hormones at MS relapse and 2-months later in 7 male patients with relapsing remitting MS, and whether there was a correlation with a specific Th1 and Th2 cytokine pattern. Our findings indicate the activation of the hypothalamic-pituitary-adrenal axis and the concomitant upregulation of pro- and anti-inflammatory cytokines during relapse. The further increase of sex hormones, in particular estradiol in our male MS patients suggest their possible implication in the physiopathology of the illness and a putative anti-inflammatory and neuroreparatory effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
