Dietary Fiber Drives IL-1β-Dependent Peritonitis Induced by

Autor:	Bruno, Jennings-Almeida, Juliana P, Castelpoggi, Erivan S, Ramos-Junior, Eliane de Oliveira, Ferreira, Regina M C P, Domingues, Juliana, Echevarria-Lima, Robson, Coutinho-Silva, Aline C A, Moreira-Souza, Eliana, Mariño, Charles R, Mackay, Dario S, Zamboni, Maria, Bellio, Julio, Scharfstein, Leandro A, Lobo, Ana Carolina, Oliveira
Rok vydání:	2020
Předmět:	Dietary Fiber Male Mice Knockout Inflammasomes Macrophages Interleukin-1beta Receptors Interleukin-1 Peritonitis Bacteroides Infections Diet Bacteroides fragilis Mice Inbred C57BL Disease Models Animal Mice NLR Family Pyrin Domain-Containing 3 Protein Animals Signal Transduction
Zdroj:	Journal of immunology (Baltimore, Md. : 1950). 206(10)
ISSN:	1550-6606
Popis:	Intestinal barrier is essential for dietary products and microbiota compartmentalization and therefore gut homeostasis. When this barrier is broken, cecal content overflows into the peritoneal cavity, leading to local and systemic robust inflammatory response, characterizing peritonitis and sepsis. It has been shown that IL-1β contributes with inflammatory storm during peritonitis and sepsis and its inhibition has beneficial effects to the host. Therefore, we investigated the mechanisms underlying IL-1β secretion using a widely adopted murine model of experimental peritonitis. The combined injection of sterile cecal content (SCC) and the gut commensal bacteria
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::54538940c7fe7ba17e53907aa2741a2b https://pubmed.ncbi.nlm.nih.gov/33941658 Zobrazit plný text záznamu