| Autor: |
G G, Nicolas, G, LaPointe, M C, Lavoie |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
The West Indian medical journal. 59(6) |
| ISSN: |
0043-3144 |
| Popis: |
To compare the in vitro activity of mutacins D-123.1 and F-59.1 against different bacteria including antibiotic-resistant strains, in order to evaluate their application potential.The antibacterial activity spectrum of purified F-59.1 and the MIC and MBC of F-59.1 and D-123.1 against target bacteria were determined.Most bacteria were inhibited by the purified mutacins. Mutacin F-59.1 shows a relatively wide activity spectrum. Mutacin D-123.1 has low Minimum Inhibitory Concentrations [MICs] (0.25-4 microg/ml) against human pathogens while F-59.1 has higher MICs (3.2-12.8 microg/ml) mainly against food-borne pathogens.The effectiveness of mutacins D-123.1 and F-59.1 against human and food-borne pathogens is demonstrated. Mutacin D-123.1 shows potential as a new antibiotic while F-59.1 shows promising application in food products. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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