| Autor: |
Jayaprakasam, Bolleddula, Abhi, Shah, Mohammad, Shadid, Afrand, Kamali, Michael D, Smith, Swapan K, Chowdhury |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals. 48(11) |
| ISSN: |
1521-009X |
| Popis: |
TAK-164 is an antibody-drug conjugate (ADC) comprising human anti-guanylyl cyclase C (GCC) monoclonal antibody conjugated to indolinobenzodiazepine DNA alkylator IGN-P1 through a cleavable alanine-alanine dipeptide linker. TAK-164 is currently being evaluated for the treatment of gastrointestinal cancers expressing GCC. The catabolism of TAK-164 was studied using |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
