| Autor: |
Hiromitsu, Kumada, Fumitaka, Suzuki, Naohiro, Kamiya, Madori, Orihashi, Yoshiyuki, Nakayasu, Ichimaro, Yamada |
| Rok vydání: |
2016 |
| Zdroj: |
Hepatology research : the official journal of the Japan Society of Hepatology. 47(6) |
| ISSN: |
1386-6346 |
| Popis: |
To assess the efficacy and safety of telaprevir (TVR) in combination with pegylated interferon α-2a (PEG-IFNα-2a) and ribavirin (RBV) for treatment-naïve patients and relapsed patients compared to previous TVR-based triple therapy in Japan.The study group included 35 treatment-naïve (median age, 55 years) and 19 relapsed (median age, 55 years) patients with genotype 1 hepatitis C virus infection. Patients received TVR (750 mg every 8 h) for 12 weeks, in combination with PEG-IFNα-2a and RBV.The sustained virological response (SVRTelaprevir in combination with PEG-IFNα-2a/RBV provided a high sustained virological response rate for the treatment of genotype 1 hepatitis C virus in both treatment-naïve and relapsed patients in Japan. Telaprevir-based therapy may provide a useful treatment option for patients who are difficult to treat due to NS5A (Y93, L31) and NS3/4A (D168) variants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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