| Autor: |
H I, Karlic, H, Mühlberger, B G, Pavlova, M, Pfeilstöcker, J, Salamon, E, Pittermann, R, Heinz, E, Koller |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Bone marrow transplantation. 15(6) |
| ISSN: |
0268-3369 |
| Popis: |
Detection of minimal residual disease (MRD) by analysis of the PML-RAR alpha fusion transcript using the RT-PCR method is routinely carried out on peripheral blood and bone marrow of patients with APL (AML, FAB:M3). Therapy aims to achieve repeated negative results in these patients thus confirming clinical complete remission. We report a case of APL in second complete remission in which no leukemic cells had been detected in BM and PB for 20 months, and in which PBPC-pheresis was carried out for future transplantation. In two of five pheresis PML-RAR alpha fusion transcripts were detected. This shows that the residual leukemic population may only reach detection level after enrichment by PBPC-pheresis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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