Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents

Autor: D L, Budenz, M, Pyfer, K, Singh, J, Gordon, J, Piltz-Seymour, E U, Keates
Rok vydání: 1999
Předmět:
Zdroj: Ophthalmic surgery and lasers. 30(5)
ISSN: 1082-3069
Popis: To evaluate the potential benefits, complications, and prognostic risk factors for failure of phacotrabeculectomy performed with or without 5-fluorouracil (5-FU) and mitomycin-C (MMC).Retrospective chart review of 78 patients who underwent phacotrabeculectomy during a 2-year period. Patients were divided into 3 groups, those who received 5-FU (N = 28). MMC (N = 29), or no antifibrotic agent (N = 21).All 3 groups had statistically significant lower intraocular pressures (IOP) on fewer antiglaucomatous medications at 6-month, 12-month, and last follow-up compared to preoperative levels (P.05). Intraocular pressures were lower in the group that received MMC compared to the 5-FU group, but not in the group that did not receive antimetabolites, at all time intervals measured (P.05). Black race was a strong predictor of failure of trabeculectomy (P = 009). No differences in final visual acuity or complications were found between groups.Phacotrabeculectomy is effective regardless of antimetabolite use. Race is a strong predictor of failure.
Databáze: OpenAIRE