Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes
| Autor: | Cheng, Qi, Shah, Nishank, Bröer, Angelika, Fairweather, Stephen, Jiang, Yang, Schmoll, Dieter, Corry, Ben, Bröer, Stefan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Benztropine
Male Amino Acid Transport Systems Dose-Response Relationship Drug CHO Cells Research Papers High-Throughput Screening Assays Mice Inbred C57BL Molecular Docking Simulation Mice Structure-Activity Relationship Amino Acid Transport Systems Neutral Cricetulus Diabetes Mellitus Type 2 Animals Drosophila Female |
| Popis: | The neutral amino acid transporter BA CHO-based cell line was generated, stably expressing collectrin and BWe characterized a series of novel inhibitors of the BThe tools established in this study can be widely used to identify new transport inhibitors. Using these tools, we were able to identify compounds that can be used to study epithelial transport, to induce protein restriction, or be developed further through medicinal chemistry. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|