| Autor: |
Shuo-hui, Gao, Chao, Liu, Jun, Wei, Ye, Feng |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Chinese medical journal. 126(14) |
| ISSN: |
2542-5641 |
| Popis: |
Colon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy. Downregulation of HGF/c-Met signaling pathway is an emerging therapy for cancer treatment.In this study, the inhibitory effects of c-Met phosphorylation were observed with SU11274 on different colon cancer cell lines in vitro.The results revealed the significant inhibitory effects of SU11274 on cell proliferation and cell survival, in a time and dose-dependent manner. Furthermore, the inhibitory effects of SU11274 on different subgroups of colon cancer cells via the HGF/c-Met signaling pathway were implicated in this study.The results suggested the possible selective therapeutic effects of c-Met inhibitor on colon cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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