Selective reconstitution of CD8+ cytotoxic T lymphocyte responses in immunodeficient bone marrow transplant recipients by the adoptive transfer of T cell clones
| Autor: | S R, Riddell, B A, Walter, M J, Gilbert, P D, Greenberg |
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| Rok vydání: | 1994 |
| Předmět: |
Viral Structural Proteins
Mice Inbred BALB C Immunodominant Epitopes Cytomegalovirus Immunotherapy Adoptive Immediate-Early Proteins Immunocompromised Host Mice Lymphopenia Cytomegalovirus Infections Animals Humans Antigens Viral Immunocompetence Cells Cultured Bone Marrow Transplantation T-Lymphocytes Cytotoxic |
| Zdroj: | Bone marrow transplantation. 14 |
| ISSN: | 0268-3369 |
| Popis: | The adoptive transfer of T cells specific for antigens encoded by pathogens and tumors has been an effective treatment for infections and malignancies in animal models and is potentially applicable for infections occurring in immunodeficient bone marrow transplant recipients. This article reviews recent insights derived from studies of the immunobiology of human cytomegalovirus (CMV) infection in healthy and immunodeficient hosts and the development of adoptive immunotherapy as prophylaxis for CMV infection in recipients of allogeneic bone marrow transplants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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