A prospective coagulation study including resistance to activated protein C and mutations in factors V and II in venous leg ulcers

Autor:	F, Ribeaudeau, P, Senet, J M, Cayuela, X, Fund, C, Paul, C, Robert, M L, Scrobohaci, L, Dubertret
Rok vydání:	1999
Předmět:	Adult Aged 80 and over Male Thrombomodulin Antithrombin III Leg Ulcer Factor V Blood Coagulation Disorders Middle Aged Case-Control Studies Mutation Antibodies Antiphospholipid Humans Female Prothrombin Prospective Studies Activated Protein C Resistance Aged
Zdroj:	The British journal of dermatology. 141(2)
ISSN:	0007-0963
Popis:	Hypercoagulable states have been reported to be associated with venous leg ulcers. In an attempt to investigate the prevalence of hypercoagulable states in patients with venous leg ulcers, we performed a prospective case-control study for the presence of coagulation defects in such patients, including resistance to activated protein C (APC), factor V Leiden mutation and a newly described mutation in factor II. Results were compared with those obtained in a control group. APC resistance was found in four of 33 patients tested, but only one was found to be heterozygous for the factor V Leiden mutation. Factor II mutation was found in two of 30 patients tested. Our findings show that the prevalence of coagulation abnormalities is not different in patients with venous leg ulcers from controls in our study, suggesting that only selected patients with venous ulcers and a history of recurrent deep venous thrombosis should be investigated for the presence of coagulation defects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::536bab6315fb4599cf60459d8ae80b66 https://pubmed.ncbi.nlm.nih.gov/10468797 Zobrazit plný text záznamu Plný text