Development of rheumatoid arthritis after treatment of large granular lymphocyte leukemia with deoxycoformycin

Autor:	J, Yoe, B L, Gause, B D, Curti, D L, Longo, A, Bagg, W C, Kopp, J E, Janik
Rok vydání:	1998
Předmět:	Male Antibiotics Antineoplastic Neutropenia Histocompatibility Testing Middle Aged Gene Rearrangement T-Lymphocyte Polymerase Chain Reaction Clone Cells Leukemia Lymphoid Genes T-Cell Receptor Clinical Trials Phase II as Topic Felty Syndrome HLA-DR4 Antigen Humans Pentostatin
Zdroj:	American journal of hematology. 57(3)
ISSN:	0361-8609
Popis:	The association of T-cell large granular lymphocyte (LGL) leukemia and rheumatoid arthritis is well described and it is now recognized that these patients and patients with Felty's syndrome represent different aspects of a single disease process. Most patients have rheumatoid arthritis at the time of diagnosis of LGL leukemia. This is the first detailed report of the development of rheumatoid arthritis after the diagnosis and treatment of LGL leukemia as well as the first report of rheumatoid arthritis that occurred in association with deoxycoformycin treatment. It is likely that the beneficial sustained normalization of neutrophil counts as a result of deoxycoformycin treatment played a significant role in the development of this complication. Hematological improvement occurred despite molecular genetic evidence of persistence of the abnormal T-cell clone. The role of the clonally expanded T cells in the pathogenesis of neutropenia and rheumatoid arthritis is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::53570fe3d8cb3eb301fcb12a34820312 https://pubmed.ncbi.nlm.nih.gov/9495380 Zobrazit plný text záznamu Plný text