| Autor: |
K, Yamazumi, K, Shimura, H, Maekawa, S, Muramatsu, S, Terukina, M, Matsuda |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 1(4-5) |
| ISSN: |
0957-5235 |
| Popis: |
In an abnormal fibrinogen with gamma-Met-310 to Thr substitution accompanied by an extra oligosaccharide attached to gamma-Asn-308, factor-XIIIa-mediated intermolecular gamma-dimer formation of fibrin was found to be markedly delayed. The delayed gamma-dimer formation was not due to impaired fibrin polymerization because the fibrinogen gamma-chain also failed to be efficiently cross-linked by factor XIIIa. Since fluorescent amine was normally incorporated into the abnormal gamma-chain by factor XIIIa, we conclude that the abnormal molecules were unable to align their gamma-chains in an anti-parallel fashion because of inaccessibility of the molecules with a profoundly perturbed conformation near the carboxyl terminal region of the gamma-chain included in the D domain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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