| Autor: |
Zhu, Feng, Choi, Bu Young, Ma, Wei-Ya, Zhao, Zhongliang, Zhang, Yiguo, Cho, Yong Yeon, Choi, Hong Seok, Imamoto, Akira, Bode, Ann M., Dong, Zigang |
| Jazyk: |
angličtina |
| Rok vydání: |
2006 |
| Předmět: |
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| Popis: |
The oncoprotein c-Jun is a component of the activator protein-1 transcription factor complex, which is involved in cellular proliferation, transformation, and death. The stabilization of c-Jun is critically important for its function. The phosphorylation of c-Jun by c-Jun NH(2)-terminal kinase 1 and extracellular signal-regulated protein kinases reduces c-Jun ubiquitination resulting in increased stabilization of c-Jun. In this report, we showed that COOH-terminal Src kinase (CSK) binds with and phosphorylates c-Jun at Y26 and Y170. Phosphorylation of c-Jun by CSK, in opposition to c-Jun NH(2)-terminal kinase 1 and extracellular signal-regulated protein kinases, promoted c-Jun degradation and reduced stability. By promoting c-Jun degradation, CSK helps to maintain a low steady-state level of c-Jun, thereby inhibiting activator protein-1 activity and cell transformation caused by c-Jun. These results indicated that this function of CSK controls cell proliferation under normal growth conditions and may have implications for CSK loss of function in carcinogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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