UVB-induced acantholysis in endemic Pemphigus foliaceus (Fogo selvagem) and Pemphigus vulgaris

Autor:	V M, Reis, R P, Toledo, A, Lopez, L A, Diaz, J E, Martins
Rok vydání:	2000
Předmět:	Adult Male Acantholysis Ultraviolet Rays Case-Control Studies Sunlight Humans Female Middle Aged Pemphigus Aged Autoantibodies Skin
Zdroj:	Journal of the American Academy of Dermatology. 42(4)
ISSN:	0190-9622
Popis:	The autoantibody-mediated disease in fogo selvagem (FS) is aggravated by sunlight exposure.The aim of this study was to test whether UVB exposure of uninvolved skin of patients with FS (n = 21) enhances epidermal acantholysis and in vivo binding of FS autoantibodies as compared with a control group (n = 4). Another control group included 8 patients with pemphigus vulgaris (PV).Exposure of uninvolved skin of FS to UVB induces acantholysis (15/21 patients) with in vivo binding of IgG and C3 to the epidermal intercellular spaces (17/21 patients). Similar results were found in PV (6/8 patients). The test was negative in the control group.Sunlight exposure is harmful in the clinical course of patients with FS and those with PV. Protection from sunlight should be part of the treatment of these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::531284612d71544db9acd8ce4c36d16d https://pubmed.ncbi.nlm.nih.gov/10727300 Zobrazit plný text záznamu Full Text from ScienceDirect