| Autor: |
O D, Zhukov, A H, Berdyshev, H V, Kosiakova, V M, Klimashevs'kyĭ, T M, Horid'ko, O F, Mehed', N M, Hula |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Ukrainian biochemical journal. 86(3) |
| ISSN: |
2409-4943 |
| Popis: |
The mechanisms of anti-inflammatory action of saturated N-acylethanolamine--N-stearoylethanolamine (NSE) were investigated on the rat model of nonspecific inflammation (thermal burns of the skin). The results showed that the NSE application in a form of aqueous suspension (10 mg/ml) on the damaged skin area during 12 days significantly accelerated the healing process of burned wounds. NSE also prevented the increase of 11-hydroxycorticosteroids content in the blood of rats with burns. There was also found a significant decrease of cytokines (IL-1beta, IL-6 and TNFalpha) levels under the NSE action. This way may be one of the mechanisms of NSE anti-inflammatory action. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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