| Autor: |
A, Németh, E, Nádasi, A, Beró, L, Olasz, A, Ember, A, Kvarda, L, Bujdosó, I, Arany, A, Csejtei, Zs, Faluhelyi, I, Ember |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Anticancer research. 24(6) |
| ISSN: |
0250-7005 |
| Popis: |
The aim of the study was to investigate the early effect of Transplatin (the stereo-isomer of Cisplatin) on oncogenes in inbred CBA/Ca mice. Cisplatin is commonly used for the treatment of squamous cell carcinomas of the head and neck. Cisplatin has a strong oncogene activation effect compared to the structural analogue Transplatin. Body weight equivalent amounts of a human dose of Transplatin were administered intra-peritoneally to 6- to 8-week-old, inbred, female CBA/Ca mice. Twenty-four, 48 and 72 hours after the treatment, RNA was isolated from the target organs and the expressions of c-myc, Ha-ras and p53 genes were examined. Investigation of early changes showed no significant overexpression compared to Cisplatin, which had a significant effect on oncogene expression in the "short-term" in vivo test system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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