Mitoxantrone, fluorouracil plus L-leucovorin, and vinorelbine in pretreated advanced breast cancer
| Autor: | M, Colleoni, P, Nelli, F, Gaion, G, Sgarbossa, P, Manente |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Lung Neoplasms Neutropenia Liver Neoplasms Remission Induction Leucovorin Bone Neoplasms Breast Neoplasms Vinorelbine Leukopenia Middle Aged Vinblastine Antineoplastic Agents Phytogenic Chemotherapy Adjuvant Antineoplastic Combined Chemotherapy Protocols Humans Female Fluorouracil Mitoxantrone Aged |
| Zdroj: | Oncology. 52(6) |
| ISSN: | 0030-2414 |
| Popis: | The combination chemotherapy including mitoxantrone, fluorouracil and leucovorin has proven to be effective and well-tolerated in advanced breast cancer (ABC). No data are available on the association with navelbine, a new vinka alkaloid, which has demonstrated high activity in ABC. The trial was designed to evaluate feasibility and efficacy of the association of vinorelbine to mitoxantrone, fluorouracil and L-leucovorin in patients who failed a previous regimen for ABC or who relapsed within 6 months of adjuvant chemotherapy. The schedule was as follows: mitoxantrone 6 mg/m2 days 1 and 8; L-leucovorin 250 mg/m2 days 1 and 8, fluorouracil 600 mg/m2 days 1 and 8, vinorelbine 25 mg/m2 days 1 and 8, cycles being repeated every 21 days. Twenty-five patients were enrolled and are evaluable for response and side effects. One hundred cycles of therapy have been delivered (median/patient, 4 cycles). In 41 cycles a delay was required and in 38 cycles it was necessary to administer granulocyte colony-stimulating factor for neutropenia. Seven partial remissions (28%; 95% confidence interval, 12-49%), 10 stabilizations of disease and 8 progressions were observed. Although grade 4 neutropenia was observed in 44% of the patients, no grade 3-4 infections were observed. Nonhematologic toxicities were mild or moderate and included alopecia, mucositis and phlebitis. In conclusion, the schedule employed, although correlated with a moderate activity, does not seem to be superior to other regimens with mitoxantrone, fluorouracil, and leucovorin. |
| Databáze: | OpenAIRE |
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