| Autor: |
T N, Riley, F W, Crawford |
| Rok vydání: |
1976 |
| Předmět: |
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| Zdroj: |
Journal of pharmaceutical sciences. 65(4) |
| ISSN: |
0022-3549 |
| Popis: |
Several series of N,N-diaralkyl- and N-aryloxyalkyl-N-aralkyl-beta-haloethylamines were synthesized containing centers of chirality in the aralkyl substituent and in the beta-haloethyl moiety to study the stereoselectivity of alpha-adrenolytic activity of the beta-haloethylamines. These compounds were synthesized from starting materials of known absolute configuration via synthetic schemes that did not alter the stereochemical integrity of the chiral centers. Evaluation of the alpha-adrenolytic activities of these beta-haloethylamines on rat vas deferens indicated a variable degree of stereoselectivity of adrenergic blockade, which is interpreted in terms of drug-receptor interactions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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