Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe
| Autor: | Pabla, Aguirre, Olimpo, García-Beltrán, Victoria, Tapia, Yorka, Muñoz, Bruce K, Cassels, Marco T, Núñez |
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| Rok vydání: | 2016 |
| Předmět: |
Tyrosine 3-Monooxygenase
Iron Brain MPTP Poisoning Iron Chelating Agents Mitochondria Rats Mice Inbred C57BL Rats Sprague-Dawley Disease Models Animal Mice Neuroblastoma Cytosol Neuroprotective Agents 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Coumarins Cell Line Tumor Animals Humans Monoamine Oxidase Copper |
| Zdroj: | ACS chemical neuroscience. 8(1) |
| ISSN: | 1948-7193 |
| Popis: | Disturbed iron homeostasis, often coupled to mitochondrial dysfunction, plays an important role in the progression of common neurodegenerative diseases such as Parkinson's disease (PD). Recent studies have underlined the relevance of iron chelation therapy for the treatment of these diseases. Here we describe the synthesis, chemical, and biological characterization of the multifunctional chelator 7,8-dihydroxy-4-((methylamino)methyl)-2H-chromen-2-one (DHC12). Metal selectivity of DHC12 was Cu |
| Databáze: | OpenAIRE |
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