| Autor: |
Katia, D'Ambrosio, Simone, Carradori, Stefania, Cesa, Andrea, Angeli, Simona M, Monti, Claudiu T, Supuran, Giuseppina, De Simone |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Chemical communications (Cambridge, England). 56(85) |
| ISSN: |
1364-548X |
| Popis: |
To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the "deep water". |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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