| Autor: |
Michiel, van der Flier, Gwenda, Verweel, Linda C, van der Knaap, Petronette, van Jaarsveld, Gert-Jan, Driessen, Manon, van der Lee, Nico G, Hartwig, David M, Burger |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Antiviral therapy. 13(8) |
| ISSN: |
1359-6535 |
| Popis: |
Recently, a new tablet formulation of the widely used HIV protease inhibitor lopinavir/ritonavir was licensed. Here, we present a pilot study of the pharmacokinetics of the new adult tablet formulation taken once daily in children.Lopinavir pharmacokinetics of the new adult tablet formulation were evaluated in 15 HIV type-1-infected children between 4 and 15 years of age. A target dose of 460/115 mg/m2 was administered once daily. Plasma concentrations of lopinavir over the course of 24 h were determined with a validated HPLC method.The median lopinavir dose was 498 mg/m2 (range 424-548). The mean +/- SD for lopinavir area under the 24 h curve was 217.9 +/- 44.9 mg/l x h, the maximum concentration was 14.8 +/- 2.4 mg/l and the concentration 24 h after intake was 3.1 +/- 2.6 mg/l. The half-life of lopinavir was 5.8 +/- 4.5 h and the median time to maximum concentration was 5.8 h (range 1.8-12.2). Overall, the tablet formulation resulted in greater exposure to lopinavir with less variability compared with the soft-gel capsule formulation. All children treated with the new adult tablet formulation had undetectable viral loads (50 copies/ml) during 24 weeks follow-up.The tablet formulation could probably result in improved lopinavir dosing and increases the feasibility of once-daily lopinavir/ritonavir-based regimens in children. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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