| Autor: |
A V, Polonikov, V P, Ivanov, M A, Solodilova, A I, Shveĭnov, O S, Manuĭlova, M A, Kozhukhov, M P, Tutochkina, A A, Stepchenko, I V, Bulgakova |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimentalclinical gastroenterology. (1) |
| ISSN: |
1682-8658 |
| Popis: |
The purpose of our study was to investigate whether polymorphisms -238G/A, -308G/A, and -863C/A within the promoter of the TNF-alpha gene are associated with clinical features of gastric and duodenal ulcer disease in a Russian population. DNA samples of 381 unrelated patients with gastric and duodenal ulcer disease and 216 sex- and age-matched healthy controls were used to determine the TNF-alpha gene polymorphisms by PCR-RFLP assay. Logistic regression analysis has revealed significant associations of polymorphism -308G/A with size of ulcerous defect (p=0.03) and intestinal dyspepsia (p=0.05), polymorphism -238G/A with gastric dyspepsia (p=0.04) and reflux-esophagitis (p=0.05), polymorphism -863C/A with perforation of ulcer (p=0.04). The study results highlight impact of the TNF-alpha gene polymorphisms on various clinical features in patients with peptic ulcer disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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