| Autor: |
Justyna, Paprocka, Renata, Dec, Ewa, Jamroz, Elzbieta, Marszał |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Medical science monitor : international medical journal of experimental and clinical research. 16(9) |
| ISSN: |
1643-3750 |
| Popis: |
The aim of the study was to assess diurnal melatonin secretion in children with refractory epilepsy (N=74) as compared to children without epileptic seizures (N=37) and to compare melatonin secretion in children with focal and generalized refractory epilepsy.In the study group 4 subgroups were defined: children with focal symptomatic epilepsy, focal cryptogenic epilepsy, generalized symptomatic epilepsy, and generalized cryptogenic epilepsy. Melatonin level was measured every 3 hours using the RIA method.Analysis of diurnal melatonin secretion indicated a lower level of the hormone in patients with refractory epilepsy. The daily rhythm of melatonin secretion in the study group was maintained, with a peak shift of melatonin secretion especially visible in the subgroup with generalized symptomatic refractory epilepsy in the age group between 6 months and 3 years of age.The hypothesis may be formed that a lowered level of melatonin in the study group in relation to the comparison group is the consequence of the natural course of epilepsy or is influenced by antiepileptic drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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