| Autor: |
L I, Apukhovskaia, T N, Nikiforova, Iu D, Kholodova, P A, Voziian, E V, Solodova |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Ukrainskii biokhimicheskii zhurnal (1. 58(5) |
| ISSN: |
0201-8470 |
| Popis: |
The amino acid composition, lipid-binding ability, the values of pK and binding capacity of negatively charged sites of the integral protein-3 from erythrocyte membranes are determined for rats in norm and under conditions of D-hypovitaminosis. Protein-3 binding of phosphatidyl choline and sphingomyelin considerably decreases, while that of cholesterol and lanosterol increases with the unchanged amino acid composition under conditions of D-hypovitaminosis. This leads to the enhancement of the protein electro-negativity as its carboxylic groups and histidine imidazole become more accessible for titration. An increase of the negative charge of protein-3 with D-hypovitaminosis is supposed to be responsible for inhibition of the anionic transport realized by it through the forces of electrostatic repulsion. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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