| Autor: |
Thassio R, Mesquita, Gaëlle, Auguste, Débora, Falcón, Gema, Ruiz-Hurtado, Rogelio, Salazar-Enciso, Jessica, Sabourin, Florence, Lefebvre, Say, Viengchareun, Hussein, Kobeissy, Patrick, Lechène, Valérie, Nicolas, Amaya, Fernandez-Celis, Susana, Gómez, Sandra, Lauton Santos, Eric, Morel, Angelica, Rueda, Natalia, López-Andrés, Ana Maria, Gómez, Marc, Lombès, Jean-Pierre, Benitah |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Circulation research. 122(7) |
| ISSN: |
1524-4571 |
| Popis: |
The MR (mineralocorticoid receptor) antagonists belong to the current therapeutic armamentarium for the management of cardiovascular diseases, but the mechanisms conferring their beneficial effects are poorly understood. Part of the cardiovascular effects of MR is because of the regulation of L-type CaTo analyze the molecular mechanisms by which aldosterone, through MR, modulates CaIn primary cultures of neonatal rat ventricular myocytes, aldosterone exposure for 24 hours increased in a concentration-dependent manner long cardiac CaOur results reveal that MR acts as a transcription factor to translate aldosterone signal into specific cardiac P1-promoter activation that might influence the therapeutic outcome of cardiovascular diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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