| Autor: |
R, Ramos Fernández de Soria, R, Núñez Núñez, J, Ruiz de la Hermosa, R, Gómez de Tejada, E, Blesa Sánchez |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Archivos espanoles de urologia. 42(2) |
| ISSN: |
0004-0614 |
| Popis: |
The present experimental study was carried out in 75 female Wistar rats. End-to-side vesicosigmoidostomy was performed in 65; the remaining 10 rats comprised the control group. Thirty-three rats were de-diverted at 1 and 2 months later. The site of the vesicosigmoid anastomosis was assessed histologically at 1, 2, and 3 months postoperatively in diverted rats, and at 1 and 2 months in de-diverted rats. Squamous metaplastic changes and variable degrees of transitional cell line neoplasm were observed in the diverted rats. Bladder changes did not regress significantly after de-diversion. No structural changes were observed at the level of the sigmoid. This experimental animal model confirms the oncogenic potential of mixing feces and urine, and shows that de-diversion does not achieve significant regression of bladder tumor lesions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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