Modulation of DNA repair genes induced by TLR9 agonists

Autor:	Sommariva, Michele, De Cecco, Loris, Tagliabue, Elda, Balsari, Andrea
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	ovarian cancer DNA repair chemical and pharmacologic phenomena hemic and immune systems Toll-like receptor 9 “altered” cells respiratory system immune cell chemotherapy Author's View
Zdroj:	Oncoimmunology
ISSN:	2162-402X 2162-4011
Popis:	We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::51823e27a531acbd1bb942376957b30b http://europepmc.org/articles/PMC3377000 Zobrazit plný text záznamu Plný text ve formátu PDF