Modulation of DNA repair genes induced by TLR9 agonists
Autor: | Sommariva, Michele, De Cecco, Loris, Tagliabue, Elda, Balsari, Andrea |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: | |
Zdroj: | Oncoimmunology |
ISSN: | 2162-402X 2162-4011 |
Popis: | We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response. |
Databáze: | OpenAIRE |
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