| Autor: |
N, Mairesse, P, Galand, J C, Heuson, G, Leclercq |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
Archives internationales de physiologie et de biochimie. 84(5) |
| ISSN: |
0003-9799 |
| Popis: |
The induction by estradiol-17beta (E2) in DMBA-induced mammary tumors of a protein similar to that found in the uterus of estrogen-treated rats is reported. It is called an indirect protein (IP) and was demonstrated by an increased incorporation of labeled amino acids in a specific band of polyacrylamide gel electrophoresis. All the tumors contained the receptor for estrogen. A definite IP peak was shown by using a cytosol mixture that was enriched in the IP fraction by precipitation with 80% ammonium sulphate before electrophoresis. Data indicate that IP may represent a basic feature of target tissue response to estrogen stimulation. Measurement of IP synthesis might offer a method for investigating estradiol dependence. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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