Mechanically Defined Microenvironment Promotes Stabilization of Microvasculature, Which Correlates with the Enrichment of a Novel Piezo-1
| Autor: | Aurelien, Forget, Roberto, Gianni-Barrera, Andrea, Uccelli, Melika, Sarem, Esther, Kohler, Barbara, Fogli, Manuele G, Muraro, Sandrine, Bichet, Konrad, Aumann, Andrea, Banfi, V Prasad, Shastri |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
CD11b Antigen
Sepharose Endothelial Cells Neovascularization Physiologic Cell Count Hydrogels Receptor Macrophage Colony-Stimulating Factor Mice SCID Ion Channels Monocytes Cellular Microenvironment Microvessels Leukocytes Mononuclear Animals Cell Proliferation Mechanical Phenomena Signal Transduction |
| Zdroj: | Advanced materials (Deerfield Beach, Fla.). 31(21) |
| ISSN: | 1521-4095 |
| Popis: | Vascularization is a critical step in the restoration of cellular homeostasis. Several strategies including localized growth factor delivery, endothelial progenitor cells, genetically engineered cells, gene therapy, and prevascularized implants have been explored to promote revascularization. But, long-term stabilization of newly induced vessels remains a challenge. It has been shown that fibroblasts and mesenchymal stem cells can stabilize newly induced vessels. However, whether an injected biomaterial alone can serve as an instructive environment for angiogenesis remains to be elucidated. It is reported here that appropriate vascular branching, and long-term stabilization can be promoted simply by implanting a hydrogel with stiffness matching that of fibrin clot. A unique subpopulation of circulating CD11b |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text