Content of Peripheral Blood T- and B-Cell Subpopulations in Transgenic A53T Mice of Different Age (A Model of Parkinson's Disease)

Autor:	G V, Idova, E L, Al'perina, M M, Gevorgyan, M A, Tikhonova, S Ya, Zhanaeva
Rok vydání:	2020
Předmět:	CD4-Positive T-Lymphocytes Male Mice Inbred C57BL Aging B-Lymphocytes Disease Models Animal Mice CD3 Complex Animals Parkinson Disease Locomotion
Zdroj:	Bulletin of experimental biology and medicine. 170(4)
ISSN:	1573-8221
Popis:	We analyzed the behavior and peripheral blood T- and B-cell subpopulations in mice overexpressing the mutant form of human α-synuclein (A53T) in comparison with mice of the wild type (WT) parent C57BL/6J strain. Behavioral phenotype and the content of various cell subpopulations of A53T mice depended on animal age. Young (2-month-old mice) were characterized by low emotionality and the most pronounced changes in cell subpopulation composition (an increase in CD3
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::51282e5c5fb2abed2f47c9f269ae8f30 https://pubmed.ncbi.nlm.nih.gov/33725243 Zobrazit plný text záznamu Full text from SpringerLink