| Autor: |
Andrew S, Gudeman, Serena A, Dine, Todd A, Walroth, Allison N, Boyd, Evan D, Zahn, Joseph E, Jacobson, Brian H, Mullis |
| Rok vydání: |
2021 |
| Zdroj: |
European journal of orthopaedic surgerytraumatology : orthopedie traumatologie. |
| ISSN: |
1432-1068 |
| Popis: |
The objectives of this study were to assess the incidence of vitamin D deficiency in orthopaedic trauma patients, evaluate the safety and efficacy of a vitamin D supplementation protocol, and investigate the utility of vitamin D supplementation in reducing nonunions.Three hundred seventy patients with operative tibia and/or fibula fractures were retrospectively reviewed. Both overall and matched cohorts were analysed.Ninety-eight per cent (n = 210) were found to have vitamin D insufficiency (serum 25(OH)D level 30 ng/ml). There were no cases of vitamin D toxicity following vitamin D replacement. Median follow-up vitamin D level was 22.7 ng/mL. No statistical difference between union rates was found between either the two consecutive cohorts or matched cohorts.This vitamin D replacement protocol was a safe treatment for hypovitaminosis D, but post hoc analysis shows there would need to be over 1200 matched patients to achieve adequate power. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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