[Liposome encapsulation of cystostatic drugs and starch microspheres improve tumor targeting in locoregional therapy. An animal experiment study of CC 531 liver tumor]
| Autor: | G, Berger, R, Reszka, U, Pohlen, M, Jung, S, Lucas, H J, Buhr |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2003 |
| Předmět: |
Antimetabolites
Antineoplastic Drug Evaluation Preclinical Rats Inbred Strains Starch Infusion Pumps Implantable Adenocarcinoma Magnetic Resonance Imaging Rats Drug Delivery Systems Liver Neoplasms Experimental Liposomes Tumor Cells Cultured Animals Infusions Intra-Arterial Fluorouracil Colorectal Neoplasms Neoplasm Transplantation |
| Zdroj: | Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress. 115 |
| ISSN: | 0942-2854 |
| Popis: | Systemic adjuvant chemotherapy achieves unsatisfactory results for inoperable liver tumors and metastases. Various clinical studies have shown that locoregional chemotherapy increased the survival rate by a few months. The aim of this study was to investigate tumor targeting of the most frequently used cytostatic 5-fluouracil by modifying systemic and locoregional therapy by liposome encapsulation. The tumor concentration of 5-FU encapsulated in SUV-PEG liposomes increases by a factor of 27 in systemic therapy and a factor of 90 in locoregional therapy. The tumor concentration of 5-FU increases by a factor of 8000, if the blood flow is additionally slowed by starch microspheres (Spherex) during locoregional therapy with liposome-encapsulated 5-FU. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|