| Autor: |
G, Tudó, J, González-Martín, R, Obama, J M, Rodríguez, J R, Franco, M, Espasa, P P, Simarro, G, Escaramis, C, Ascaso, A, García, M T, Jiménez De Anta |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 8(12) |
| ISSN: |
1027-3719 |
| Popis: |
Bata and Malabo districts, Equatorial Guinea, 1 March 1999 to 28 February 2001.To study the molecular epidemiology of tuberculosis (TB).During the study period, 429 patients were diagnosed with TB in the Bata and Malabo districts. A positive culture was obtained in 206 (48%) TB patients, with RFLP analysis being performed in 185 (89.8%). Ninety-two different patterns were identified. Single patterns were found in 71 strains (38.3%) and the remaining 114 strains (61.6%) were classified into 21 clusters (of 2 to 25 patients). In addition, 37 of the typing strains were resistant to one or more anti-tuberculosis drugs, and 30 were included in clusters (81%), with 21 low level isoniazid (MICor = 1 microg/ml) resistance strains in the same cluster. Statistical analysis showed that resistance to anti-tuberculosis drugs (OR 3.1; 95% CI 1.2-7.6; P = 0.014), and positive smear results (4+ grade smear) (OR 4.3; 95% CI 1.5-12; P = 0.005), were significantly more frequent among patients with clustered strains. No epidemiological links were related to clustering.The level of clustering (61.6%) observed suggests a high degree of recent transmission and a predominance of determined patterns of Mycobacterium tuberculosis strains among the population of Equatorial Guinea. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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