Levels of plasma lipid peroxide products and antioxidant status in rheumatoid arthritis

Autor: S, Kajanachumpol, M, Vanichapuntu, O, Verasertniyom, K, Totemchokchyakarn, M, Vatanasuk
Rok vydání: 2000
Předmět:
Zdroj: The Southeast Asian journal of tropical medicine and public health. 31(2)
ISSN: 0125-1562
Popis: Oxygen free radicals have been implicated as mediators of tissue damage in patients with rheumatoid arthritis. The aim of our study was to assess the lipid peroxide products and antioxidant status in rheumatoid arthritis patients (RA). The study involved determination of two plasma lipid peroxide products, malondialdehyde (MDA) and conjugated dienes (CD), two plasma antioxidant vitamins (C and E) in 91 RA patients and 26 healthy subjects. The results showed that rheumatoid patients had increased plasma CD but not MDA and decreased plasma vitamin E, when properly expressed per unit cholesterol and triglyceride. This finding suggested that RA patients had increased oxidant stress that might play a role in the tissue damage and inflammation process of this disease.
Databáze: OpenAIRE