Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation
| Autor: | A, Coxon, X, Cullere, S, Knight, S, Sethi, M W, Wakelin, G, Stavrakis, F W, Luscinskas, T N, Mayadas |
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| Rok vydání: | 2001 |
| Předmět: |
Mice
Knockout Microvilli Anti-Glomerular Basement Membrane Disease Neutrophils Kidney Glomerulus Receptors IgG Macrophage-1 Antigen Antigen-Antibody Complex GPI-Linked Proteins Antibodies Basement Membrane Mice Inbred C57BL Mice Antigens CD CD18 Antigens Cell Adhesion Leukocytes Mononuclear Animals Humans K562 Cells Autoantibodies |
| Zdroj: | Immunity. 14(6) |
| ISSN: | 1074-7613 |
| Popis: | Neutrophil accumulation is a hallmark of immune complex-mediated inflammatory disorders. Current models of neutrophil recruitment envision the capture of circulating neutrophils by activated endothelial cells. We now demonstrate that immobilized immune complexes alone support the rapid attachment of neutrophils, under physiologic flow conditions. Initial cell tethering requires the low-affinity Fc gamma receptor IIIB (Fc gamma RIIIB), and the beta(2) integrins are additionally required for the subsequent shear-resistant adhesion. The attachment function of Fc gamma RIIIB may be facilitated by its observed presentation on neutrophil microvilli. In vivo, in a model of acute antiglomerular basement membrane nephritis in which immune complexes are accessible to circulating neutrophils, Fc gamma RIII-deficient mice had a significant reduction in neutrophil recruitment. Thus, the interaction of immune complexes with Fc gamma RIII may mediate early neutrophil recruitment in immune complex-mediated inflammation. |
| Databáze: | OpenAIRE |
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