Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients

Autor:	K, Simpson, R E, Jones, J W, Grimstead, R, Hills, C, Pepper, D M, Baird
Rok vydání:	2014
Předmět:	Adult Aged 80 and over Male Telomere Homeostasis Breast Neoplasms Genome instability Middle Aged Telomere Prognosis Disease-Free Survival Survival Rate Breast cancer Biomarkers Tumor Humans Female Research Articles Aged Follow-Up Studies Research Article
Zdroj:	Molecular Oncology
ISSN:	1878-0261
Popis:	Telomere dysfunction and fusion can drive genomic instability and clonal evolution in human tumours, including breast cancer. Telomere length is a critical determinant of telomere function and has been evaluated as a prognostic marker in several tumour types, but it has yet to be used in the clinical setting. Here we show that high‐resolution telomere length analysis, together with a specific telomere fusion threshold, is highly prognostic for overall survival in a cohort of patients diagnosed with invasive ductal carcinoma of the breast (n = 120). The telomere fusion threshold defined a small subset of patients with an extremely poor clinical outcome, with a median survival of less than 12 months (HR = 21.4 (7.9–57.6), P Highlights High‐resolution telomere length analysis is highly prognostic for overall survival.Independent of ER, PGR, HER2 status, NPI and grade.Dominant variable in multivariate analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5082a54569641ff2c8fc04ced68359ff https://pubmed.ncbi.nlm.nih.gov/25752197 Zobrazit plný text záznamu Plný text