Oncostatin M and IL-6 induce u-PA and VEGF in prostate cancer cells and correlate in vivo
| Autor: | Thomas Werner, Weiss, Rainer, Simak, Christoph, Kaun, Gersina, Rega, Heinz, Pflüger, Gerald, Maurer, Kurt, Huber, Johann, Wojta |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Interleukin-6 Prostate Prostatic Hyperplasia Prostatic Neoplasms Epithelial Cells Oncostatin M Ligands Urokinase-Type Plasminogen Activator Gene Expression Regulation Neoplastic Cell Line Tumor Cytokine Receptor gp130 Humans RNA Messenger Neoplasm Metastasis Aged |
| Zdroj: | Anticancer research. 31(10) |
| ISSN: | 1791-7530 |
| Popis: | Oncostatin M (OSM) and interleukin-6 (IL-6) are growth factors for prostate cancer (PC). Vascular endothelial growth factor (VEGF) and urokinase-type plasminogen-activator (u-PA) have been implicated in tumour progression. A possible interaction between IL-6, OSM, u-PA and VEGF in PC was investigated.Primary prostate epithelial cells (PPEC) and DU-145 PC cells were treated with IL-6 or OSM and the effects on u-PA and VEGF expression were studied. Plasma levels of IL-6, OSM, u-PA and VEGF were determined in patients with or without PC.In DU-145 cells, OSM and IL-6 up-regulated u-PA and VEGF significantly. Higher levels of IL-6 and OSM in metastasising PC than in nonmetastasising PC and benign prostatic hyperplasia (BPH) and correlations between IL-6, OSM, u-PA and VEGF were found.OSM and IL-6 increase u-PA and VEGF in DU-145 cells but not in PPEC and possibly, by promoting matrix degradation and angiogenesis, could play a role in the pathogenesis of prostate cancer. |
| Databáze: | OpenAIRE |
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