| Autor: |
Kelvin Olutimilehin, Jolayemi, Mohammed, Mamman, Dahiru, Sani, Magdalene Ogbonneya, Okoronkwo, Collins Chimezie, Udechukwu, Ochuko, Orakpoghenor |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
J Parasit Dis |
| ISSN: |
0971-7196 |
| Popis: |
This study assessed the effects of artemether and in combination with diminazene aceturate on parasitaemia, weight, haematology and pathology induced by experimentally Trypanosoma brucei brucei infection in Wistar rats. Fifty adult rats comprising 25 each of males and females were assigned into 5 groups of ten rats (five males and five females). Rats in group I was uninfected while groups II-V were infected with T b brucei. Groups II were untreated; III administered diminazene aceturate once; IV and V administered artemether only and in combination with diminazene aceturate respectively for 5 days. Parasitaemia was determined daily, blood was collected for haematology and weight obtained every four days for a period of 32 days. At 24 days post-treatment, rats were humanely euthanized and organs harvested for pathological examination. Results revealed parasitaemia at day 4 post-infection, significant (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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