Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration† †Electronic supplementary information (ESI) available: Experimental section, NMR, mass and PL spectrum of TTA, HOMO, LUMO, photophysical properties, cell viability, photostability, and two-photon excited fluorescence spectrum of TTS. See DOI: 10.1039/c7sc04820c
| Autor: | Qin, Wei, Zhang, Pengfei, Li, Hui, Lam, Jacky W. Y., Cai, Yuanjing, Kwok, Ryan T. K., Qian, Jun, Zheng, Wei, Tang, Ben Zhong |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Chemical Science |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | A successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features is reported. The AIE dots can be utilized as efficient fluorescent probes for in vivo deep-tissue imaging with high penetration depth and high contrast. Reported here is a successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features, donor–acceptor structures, and intense charge transfer effects. These luminogens show no aggregation caused emission quenching in the solid state and have high quantum efficiency. They can be fabricated into AIE dots by a simple nanoprecipitation procedure. The AIE dots exhibit high brightness, a large Stokes shift, good biocompatibility, satisfactory photostability, and a high two-photon absorption cross section. The AIE dots can be utilized as highly efficient fluorescent probes for in vivo deep-tissue imaging by a two-photon technique, which outperforms the one-photon technique under the same experimental conditions, in terms of penetration depth and image contrast. This is the first report of using highly emissive AIE dots for the accurate measurement of capillary diameters in mouse ears. Such a strategy sheds light on the development of efficient solid state red/NIR emitters for biological applications. |
| Databáze: | OpenAIRE |
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