A convenient assay for estimating the possible involvement of efflux of fluoroquinolones by Streptococcus pneumoniae and Staphylococcus aureus: evidence for diminished moxifloxacin, sparfloxacin, and trovafloxacin efflux
| Autor: | R, Beyer, E, Pestova, J J, Millichap, V, Stosor, G A, Noskin, L R, Peterson |
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| Rok vydání: | 2000 |
| Předmět: |
Aza Compounds
Staphylococcus aureus Reserpine Moxifloxacin Drug Resistance Microbial Microbial Sensitivity Tests biochemical phenomena metabolism and nutrition bacterial infections and mycoses Streptococcus pneumoniae Anti-Infective Agents Mechanisms of Resistance Quinolines heterocyclic compounds Naphthyridines Fluoroquinolones |
| Zdroj: | Antimicrobial agents and chemotherapy. 44(3) |
| ISSN: | 0066-4804 |
| Popis: | We developed a simplified assay for estimating efflux by measuring the effect of reserpine on the growth of Streptococcus pneumoniae and Staphylococcus aureus over 7 h. Reserpine enhanced ciprofloxacin and levofloxacin 17 to 68%. The hydrophobic drug trovafloxacin and the drug moxifloxacin, with a bulky C-7 substituent but hydrophilicity similar to that of levofloxacin, showed little (0 to 11%) reserpine-enhancing effect. The ease of resistant mutant strain selection correlated with efflux susceptibility. |
| Databáze: | OpenAIRE |
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