| Autor: |
Urszula, Grabowskal, Timothy J, Chambers, Masahiro, Shiroo |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Current opinion in drug discoverydevelopment. 8(5) |
| ISSN: |
1367-6733 |
| Popis: |
Cathepsin K is abundantly and selectively expressed in osteoclasts where it plays a critical role in bone degradation. Cathepsin K inhibitors are the first antiresorptive agents that prevent bone loss while allowing bone formation to continue, thereby enhancing the quality and ultimately the strength of bone. The development of cathepsin K inhibitors requires appropriate cell-based assays and animal models. Advances in reversible cathepsin K inhibitor design from January 2004 are reviewed herein. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
