Peptic ulcer does not increase the risk of dementia

Autor:	Choi, Hyo Geun, Soh, Jae Seung, Lim, Jae Sung, Sim, Song Yong, Jung, Yoon Jung, Lee, Suk Woo
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Aged 80 and over Male Peptic Ulcer Databases Factual Observational Study Middle Aged Risk Assessment Causality nested case-control study Alzheimer Disease Case-Control Studies Republic of Korea cohort study Humans epidemiology Female Longitudinal Studies peptic ulcer Research Article dementia Aged
Zdroj:	Medicine
ISSN:	1536-5964 0025-7974
Popis:	Studies have shown that peptic ulcer disease (PUD) increases the risk of dementia via the mechanism of systemic inflammation. We examined the association between PUD and the risk of dementia using a population-based national sample cohort from South Korea. Using the national cohort study from the Korean National Health Insurance Service, we extracted data for patients with dementia (n = 11,434) and for 1:4 matched control participants (n = 45,736) and then analyzed the previous histories of PUD from 2002 to 2013 using conditional logistic regression analyses. The controls were matched to the patients according to age, sex, income, region of residence, and past medical history. Subgroup analyses were performed based on age and sex. There was no statistically significant difference in the incidence of PUD between the dementia and control groups (18.0% vs 17.4%, P = .107). The adjusted odds ratio (OR) for PUD was 0.92 (95% confidence interval [CI] = 0.88–0.97, P = .002). In the subgroup analysis based on age, the adjusted ORs for PUD were 0.93 (95% CI = 0.88–0.99) in the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4feca89b4d93bab4a6294e61aa6367fb http://europepmc.org/articles/PMC7437840 Zobrazit plný text záznamu