| Autor: |
R T, Dowell, L A, Sordahl, J N, Lindsey, H L, Stone, H H, Erickson |
| Rok vydání: |
1975 |
| Předmět: |
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| Zdroj: |
Aviation, space, and environmental medicine. 46(11) |
| ISSN: |
0095-6562 |
| Popis: |
Myocardial biochemical systems which are sensitive to hypoxic and ischemic insult were studied to determine the possible etiology of ventricular endocardial hemorrhage in miniature swine following +GZ stress. Unanesthetized animals were subjected to a single, 120-s +9 GZ acceleration. Approximately 1-2 h following +GZ exposure, the animals were anesthetized and the hearts removed for analyses. Acceleration exposure resulted in the loss of acid phosphatase enzyme activity from the membrane-bound lysosomal fraction with concomitant increased activity in the soluble fraction. This suggests that lysosomal membrane integrity had been disrupted. Mitochondrial preparations from +GZ-stressed hearts exhibited marked increases in active respiratory rate and rate of calcium transport while oxidative phosphorylation efficiency was unchanged. The results clearly indicate that +GZ acceleration is capable of altering myocardial biochemical systems. However, the results tend to suggest that these alterations in cellular processes may be mediated by influences other than hypoxia or ischemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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