Simultaneous detection of valine and lactate using MEGA-PRESS editing in pyogenic brain abscess

Autor:	Thomas, Lange, Cheng-Wen, Ko, Ping-Hong, Lai, Michael, Dacko, Shang-Yueh, Tsai, Martin, Buechert
Rok vydání:	2016
Předmět:	Magnetic Resonance Spectroscopy Brain Brain Abscess Humans Reproducibility of Results Signal Processing Computer-Assisted Valine Lactic Acid Sensitivity and Specificity Algorithms Biomarkers Molecular Imaging
Zdroj:	NMR in biomedicine. 29(12)
ISSN:	1099-1492
Popis:	Valine and lactate have been recognized as important metabolic markers to diagnose brain abscess by means of MRS. However, in vivo unambiguous detection and quantification is hampered by macromolecular contamination. In this work, MEGA-PRESS difference editing of valine and lactate is proposed. The method is validated in vitro and applied for quantitative in vivo experiments in one healthy subject and two brain abscess patients. It is demonstrated that with this technique the overlapping lipid signal can be reduced by more than an order of magnitude and thus the robustness of valine and lactate detection in vivo can be enhanced. Quantification of the two abscess MEGA-PRESS spectra yielded valine/lactate concentration ratios of 0.10 and 0.27. These ratios agreed with the concentration ratios determined from concomitantly acquired short-T
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4fc9a2fe625b328f23eda168b057e743 https://pubmed.ncbi.nlm.nih.gov/27779348 Zobrazit plný text záznamu Plný text