Effect of cisapride and cimetidine on 24-hour intraesophageal pH monitoring in patients with gastroesophageal reflux disease

Autor:	J, Chojnacki, W, Tkaczewski, P, Wichan, K, Grzegorczyk, G, Klupińska
Rok vydání:	1992
Předmět:	Adult Cisapride Esophagus Piperidines Gastroesophageal Reflux Humans Serotonin Antagonists Hydrogen-Ion Concentration Middle Aged Cimetidine
Zdroj:	Materia medica Polona. Polish journal of medicine and pharmacy. 24(3)
ISSN:	0025-5246
Popis:	In 16 patients with symptomatic gastroesophageal reflux disease (GERD) 24-h intraesophageal pH monitoring (Medilog 1010, Oxford) was carried out after placebo, cisapride (4 x 5 mg) and cimetidine (3 x 200 mg plus 400 mg at bedtime). The per cent time at which intraesophageal pH4.0 (refluxive time) was analysed. Cisapride shortened daytime and postprandial refluxive time from 16.1 +/- 14.5% and 12.6 +/- 9.2% to 5.1 +/- 4.4% and 7.5 +/- 6.5%, respectively (p0.01, p0.05). Whereas, cimetidine shortened particularly night refluxive time from 24.7 +/- 14.1% to 8.8 +/- 6.9% (p0.01) and total time from 20.4 +/- 12.8% to 12.0 +/- 6.4% (p0.05).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4fc69199e63d86b73dd65dbaa65fbb1b https://pubmed.ncbi.nlm.nih.gov/1307654 Zobrazit plný text záznamu