| Autor: |
K W, Riggs, J E, Axelson, D W, Rurak, D A, Hasman, B, McErlane, M, Bylsma-Howell, G H, McMorland, R, Ongley, J D, Price |
| Rok vydání: |
1983 |
| Předmět: |
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| Zdroj: |
Journal of chromatography. 276(2) |
| Popis: |
An electron-capture gas-liquid chromatographic assay for metoclopramide using cross-linked fused silica capillary columns which provides improved selectivity and sensitivity is reported. A 25 m X 0.31 mm fused silica capillary column was used for all analyses. Linearity was observed in the range of 4--40 ng of metoclopramide base per 0.25--0.5 ml of plasma. This represents from ca. 0.9--9.0 pg at the detector employing a split ratio of 30:1 and an injection volume of 2 microliters. Applicability of the method is demonstrated by the analysis of human and sheep plasma (maternal, fetal and neonatal) from metoclopramide placental transfer studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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