Clinical outcome from hematopoietic cell transplant patients with bloodstream infection caused by carbapenem-resistant P. aeruginosa and the impact of antimicrobial combination in vitro

Autor:	Jessica Fernandes, Ramos, Gleice, Leite, Roberta Cristina Ruedas, Martins, Camila, Rizek, Sabri Saeed, Al Sanabani, Flavia, Rossi, Thais, Guimarães, Anna Sara, Levin, Vanderson, Rocha, Silvia Figueiredo, Costa
Rok vydání:	2021
Předmět:	Adult Male Adolescent Colistin Hematopoietic Stem Cell Transplantation Meropenem Microbial Sensitivity Tests Middle Aged Anti-Bacterial Agents Young Adult Carbapenem-Resistant Enterobacteriaceae Carbapenems Sepsis Pseudomonas aeruginosa Humans Female Pseudomonas Infections Brazil
Zdroj:	European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 41(2)
ISSN:	1435-4373
Popis:	Bloodstream infection (BSI) caused by carbapenem-resistant P. aeruginosa (CRPA) has high mortality in hematopoietic stem cell transplant (HSCT) recipients. We performed MIC, checkerboard, time-kill assay, PFGE, PCR, and whole genome sequence and described the clinical outcome through Epi Info comparing the antimicrobial combination in vitro. Mortality was higher in BSI caused by CRPA carrying the lasB virulence gene. The isolates were 97% resistant to meropenem displaying synergistic effect to 57% in combination with colistin. Seventy-three percent of the isolates harbored bla
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::4f7a25c883fe7a54d3d6f9f6b9fb47a8 https://pubmed.ncbi.nlm.nih.gov/34651217 Zobrazit plný text záznamu Full text from SpringerLink